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2020/05/18

Moderna's experimental coronavirus vaccine shows promise in early-stage study

  

Moderna Inc.
 said on Monday its experimental COVID-19 vaccine produced antibodies that could "neutralize" the new coronavirus in patients in a small early stage clinical trial.

 The levels of the antibodies were similar to those in blood samples of people who have recovered from COVID-19, early results from the study conducted by the National Institutes of Health showed.

 Participants were given three different doses of the vaccine and Moderna said it saw dose-dependent increase in immunogenicity, the ability to provoke an immune response in the body.

 The vaccine, mRNA-1273, was also found to be generally safe and well tolerated in the early-stage study, the drug developer said.

 Moderna leads global efforts in developing a vaccine for the new coronavirus and last week, won the U.S. health agency's "fast track" label to speed up the regulatory review. It is looking to begin late-stage trials in July.

2020/04/11

Favilavir Antiviral Becomes First Approved Drug to Treat Coronavirus in China



Fujifilm’s Antiviral Becomes First Approved Drug to Treat Coronavirus in China

By HospiMedica International staff writers
Posted on 23 Mar 2020
Fujifilm Toyama Chemical’s (Tokyo, Japan) flu drug Favilavir, which is currently being promoted with the label, Avigan, has become the first-ever antiviral medicine to be approved for use as a treatment for COVID-19 in China. The National Medical Products Administration of China has approved Favilavir for treating the now-declared pandemic illness after it appeared to be effective in coronavirus patients during clinical studies.

Favilavir, which has proven to be an effective antiviral drug for fighting RNA infections by inhibiting the RNA-dependent RNA polymerase, or RdRp, is mainly used for treating influenza in Japan and China. According to medical authorities in China, Favipiravir had delivered encouraging outcomes in clinical trials of 340 coronavirus-infected patients in Wuhan and Shenzhen. The Ministry of Science and Technology of China has stated that Favilavir was shown to prevent COVID-19 from spreading and further damaging the health of patients in clinical studies. According to reports, the patients in Shenzhen who were administered Favilavir turned negative for the coronavirus after a median of four days after becoming positive, as compared to a median of 11 days for patients who were not treated with the drug. Additionally, X-rays showed improvements in the lung condition of 91% of the patients who were administered Favipiravir, as compared to 62% of patients who were not treated with the drug.

Despite its potential, the US Food and Drug Administration (FDA) has not yet regarded Favilavir as an effective treatment medicine for coronavirus. Nevertheless, doctors in Japan are said to be conducting clinical studies of Favilavir on coronavirus patients having mild to moderate symptoms in the hope of preventing the virus from multiplying in the patients.

2020/04/05

Turkey: 86-year-old woman beats COVID-19


An 86-year-old Turkish woman became a source of inspiration for those suffering from coronavirus as she beat the disease despite suffering from multiple chronic health conditions.
The novel coronavirus has so far claimed 501 lives in Turkey, which has registered almost 24,000 COVID-19 cases, while 786 others have recovered got and discharged from hospitals.
Among the recovered, there is Rasmiye Isik.
Before COVID-19 diagnosis, Isik already suffered from heart and lung problems and she is likely to have contracted the virus from her son and daughter-in-law, who previously went to Saudi Arabia for their Umrah pilgrimage.
The couple was diagnosed with coronavirus on March 18 and their treatment started immediately.
Meanwhile, Isik also began to cough and was taken to a healthcare center, where she tested positive on March 22.
After successful treatment, Isik and her children were discharged from the hospital.
“I’ve beaten the disease, I’m so happy,” she said. “May Allah protect everyone from such trouble.”
Thankful for her recovery, she called on people to stay at home in a bid to prevent the spread of the virus.
Data compiled by the U.S.-based Johns Hopkins University shows worldwide infections surpassing 1.2 million with over 66,500 deaths.
An excess of 252,000 people has recovered.

Russia testing vaccines against coronavirus Pre-clinical studies of vaccine prototypes to end by June 2


Russia has been testing several vaccines and eight drugs to treat severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2 commonly known as COVID-19, an official said Wednesday.
Doctors found antibodies for the virus in the blood of 11 patients who recovered at the end of March, Vice Prime Minister Tatyana Golikova said at a virtual government meeting with Russia's President Vladimir Putin.
A test-system that allows scientists to study the efficiency of vaccines has been produced and several vaccines prototypes have been developed with pre-clinical studies expected to be finished by June 22, and there are already 60 volunteers ready to participate in clinical tests, said Golikova.
In addition, eight drugs that are already in use are being studied to potentially fight the virus with final conclusions announced by April 10, she said.

2020/04/04

FDA-approved Drug Ivermectin found to inhibit the replication of covid-19 in vitro by Monash university

Ivermectin is an FDA-approved broad spectrum anti-parasitic agent that in recent years we, along with other groups, have shown to have anti-viral activity against a broad range of viruses in vitro.

The causative agent of the current COVID-19 pandemic, SARS-CoV-2, is a single stranded positive sense RNA virus that is closely related to severe acute respiratory syndrome coronavirus (SARS-CoV). Studies on SARS-CoV proteins have revealed a potential role for IMPĪ±/Ī²1 during infection in signal-dependent nucleocytoplasmic shutting of the SARS-CoV Nucleocapsid protein that may impact host cell division. In addition, the SARS-CoV accessory protein ORF6 has been shown to antagonize the antiviral activity of the STAT1 transcription factor by sequestering IMPĪ±/Ī²1 on the rough ER/Golgi membrane. Taken together, these reports suggested that ivermectin’s nuclear transport inhibitory activity may be effective against SARS-CoV-2.

2020/04/01

Car power windows are very dangerous for children left in car


Covid19 countries breakthrough rallies in March 2020


2019/07/06

Amazing Luxury Camping Retreats to Visit


Camping always sounds fun until you actually do it. The abundant planning it requires, not to mention the work it takes to set up and break down a campsite, can make the experience more stressful than delightful.For those who want to get back to nature, but with luxe amenities and less hassle, glamping — or glamorous camping — has become a popular alternative option.
The tents of traditional camping and luxurious glamping might all be made from canvas, but that’s where the similarities end. Think private bathroom. Real beds. Hot water. Air conditioning. In some cases, a private butler. All while enjoying spectacular views of sweeping vistas, incredible wildlife and unforgettable coastlines. This is nature served on a silver spoon.
At these luxury camping spots around the world, you’ll be far from roughing it.

Under Canvas Moab - Utah, United States
Moab is an outdoor enthusiast’s paradise, with activities for all seasons, from biking, hiking and white-water rafting in warmer months to snowshoeing and cross-country skiing once snow has fallen. It’s the ideal setting for a campsite, and Under Canvas delivers on the promise. Tents feature spectacular views of both canyons and plateaus, and both Arches National Park and Canyonlands National Park are minutes away.
Though Under Canvas offers a range of accommodations, its deluxe safari tents stand out; each comes outfitted with a private bathroom and a spacious deck with plenty of seating.
Daytime activities are capped with nights by the campfire, listening to live music and cooking s’mores.

The Resort at Paws Up - Montana, United States
Spending time on a working cattle ranch in Montana might not sound glamorous, but the safari-style tents at this camp rival the accommodations found at four-star resorts; features include sweeping decks with Adirondack chairs and bathrooms boasting heated slate flooring and “Montana size” (read: very large) showers.
When not eating smores at their private dining pavilion or enjoying a treatment at the resort spa, guests can experience the wild west by partaking in fly-fishing, whitewater rafting, horseback riding or cattle driving.
But the most memorable experience is a horse-drawn wagon ride down to Blackfoot River — the river that inspired the novel and movie “A River Runs Through It” — for an authentic chuck wagon dinner, where the food is cooked over an open flame. A camping butler is on hand to ensure the rustic experience doesn’t sacrifice luxury.

Clayoquot Wilderness Resort - British Columbia, Canada
Nestled between mountains on the rugged Pacific coast of Vancouver Island lies remote Clayoquot Wilderness Resort, accessible by seaplane from Vancouver or by boat from nearby Tofino. Posh tents emphasize comfort with wood stoves (necessary even on summer nights), heated bathroom floors and private outdoor showers.
Wilderness guides are on hand to show visitors the riches of the Clayoquot Sound with tailored adventures, such as river kayaking, surfing, whale-watching, archery, rapelling, horseback riding and biking. For the truly adventurous, there’s Cloud Day, a helicopter flight to a “remote alpine playground” 4,500 feet above sea level, near the top of Ursus Mountain. There, visitors can pick and choose their activities for the day — be it kayaking, stand-up paddle boarding, fishing, yoga or just chilling with a glass of wine in an Adirondack chair, taking in sweeping views of the sound and surrounding slopes.

Four Seasons Tented Camp Golden Triangle - Chiang Rai, Thailand
If money is no object, this all-inclusive glamping resort in northern Thailand is a must-book. Tents feature handcrafted custom furniture and showcase stunning views of the surrounding Ruak River and bamboo jungles. All the tents have luxe bathtubs and outdoor rain showers, and special deluxe tents additionally feature wooden hot tubs, perfect for late-night soaks.
With just 15 tents, guests can have truly customized experiences as they get to know their neighbors — the elephants that live at the resort. Partnering with the Golden Triangle Asian Elephant Foundation, the Four Seasons gives guests opportunities to observe and interact with these gentle giants. In addition to shadowing mahouts as they care for the elephants, guests can hike up to Camp Peak, the resort’s highest point, alongside them, and even eat breakfast with them as the sun rises over the mountains.
For those looking to see more culture and go further afield, tour guides can be hired through the Four Seasons for day trips to Laos and Burma.

Tiger Tops Elephant Camp - Chitwan National Park, Nepal
At this camp in the Himalayan region of Nepal, guests don’t just walk among elephants — they wake up among them.
Situated on the edge of Chitwan National Park, amid tropical gardens, Tiger Tops is comprised of custom-made, fully-furnished tents right in the middle of a herd of elephants. Visitors can enjoy their morning coffee overlooking the elephants before joining them on a jungle walk or a trip to the river to watch them bathe. A jeep ride into the jungle promises sightings of more exotic creatures, including rhinos, wild boars and tigers.
The camp offers comfort to its visitors in the form of private bathrooms and electricity — and, crucially, aims to offer the same degree of well-being to its resident wildlife. There’s no chance of riding an elephant at Tiger Tops; the elephants live chain-free, and visitors are encouraged to get up close and personal by simply observing their daily routines.

Patagonia Camp - RegiĆ³n Metropolitana, Chile
Located in a forest of beech trees on the shores of tranquil Lake Toro, Patagonia Camp is a peaceful base for travelers exploring Torres del Paine National Park. From the well-appointed yurts, guests enjoy incredible views of the lake and the granite peaks of Paine Massif. Those lucky enough to book the superior yurt enjoy the additional luxurious touch of a private Jacuzzi.
The camp organizes expertly guided treks for all activity and comfort levels. For those not interested in hiking, there are fishing rods, paddle boards and kayaks available, as well as a small beach to explore. Guests can mingle back at camp in the lounge and restaurant, where traditional Chilean fare is served and the best of regional wine varietals flow. At the end of the day, travelers sleep under the night sky without feeling the chill of the night air — each yurt features a glass roof for optimal star-gazing.

Aman-i-Khas - Rajasthan, India
Set in a brushwood forest on the edge of Ranthambore National Park in India, the safari outpost Aman-i-Khas is made up of 10 luxe tents with soaring canopies and sunken marble bathtubs. Inspired by the rich Mughal traveling tents of the past, the accommodations are spacious, light and airy. A-list service comes in the form of personalized butlers, on hand as needed and during morning tea.
The real appeal here, though, is what lies beyond the camp. A safari guide leads guests on a jeep ride into the national park to see crocodiles, leopards, sambar deer and — if they’re lucky — Bengal tigers. Travelers may also enjoy a camel safari through the villages, followed by sunset drinks overlooking the rugged landscapes of Ranthambhore.

Treebones Resort - California, United States
The oceanfront yurts at Treebones Resort on the Big Sur coastline are spacious and cozy, with private decks offering spectacular views of the Pacific Ocean. But the epitome of the glamping experience is the Autonomous Tent, a cocoon-shaped dwelling with its own large deck and fire pit, located at the edge of the resort. Unlike the other yurts, this one comes with an en-suite bathroom, including a clawfoot shower.
During daylight, guests can explore the picturesque coastline on foot or by sea kayak, with a private tour guide to show them the best trails and views. Back at camp, they can relax at the spa or in the heated pool, before taking in sublime sunset views.

Kapama Buffalo Camp - Kapama Private Game Reserve, South Africa
At Kapama Buffalo Camp, set high in the treetops of a private game reserve, travelers sleep in finely appointed private tents and awake to lions roaring in the distance. Ten luxury tents, propped up on stilts and connected by wooden walkways, boast rustic charm and unspoiled views of the reserve where wildlife roam freely.
Not surprisingly considering its location, the resort is known for its safari excursions. Guests are matched up with a driver and tracker who ensure a safe, memorable experience during morning and evening game drives. Sightings of the elusive “Big Five” animals —  lions, leopards, rhinoceroses, elephants and Cape buffaloes — are all but guaranteed.
At night, travelers can soak in their tent bathtub before enjoying traditional African cuisine served beside a roaring fire. With a maximum occupancy of only 20 guests, the experience promises the utmost in exclusivity.

Dunton River Camp - Colorado, United States
Perched on the banks of the Dolores River in the San Juan Mountains of Colorado, this camp was formerly a 19th century cattle ranch, and features eight luxury tents where guests can unwind to the sights and sounds of Mother Nature during the summer months.
The bespoke accommodations include modern conveniences as well as spacious king beds and large soaking tubs. Each tent also comes with two mountain bikes for exploring the surrounding terrain. For R&R, the Spa Tent offers massages utilizing hot stones sourced straight from the Dolores River.

Anegada Beach Club - Anegada, British Virgin Islands
Most people haven’t heard of Anegada, the most remote of the British Virgin Islands. But it’s precisely the island’s isolation that makes it such an ideal setting for this glamping resort, featuring an island's version of tents -- rustic-chic,thatched-roof palapas.
King beds, daybeds, fully equipped bathrooms and private oceanfront decks with side-by-side bathtubs make for a luxurious stay. For outdoor recreation, the ocean beckons; snorkelers and scuba divers will be amazed by the marine life seen in the coral reefs surrounding the island. Sun worshipers and beachcombers, meanwhile, will enjoy the quiet shores. And those up for more adventure can try out kiteboarding or bonefishing.

Entamanu Ngorongor - Ngorongoro Conservation Area, Tanzania
With unrivaled views into the 3,000-foot deep Ngorongoro crater and across the Serengeti, Entamanu Ngorongoro is the ideal spot for travelers looking for extra comfort in Northern Tanzania. The retreat’s six luxury tents include en-suite bathrooms and indoor heating, not to mention generous living spaces with plush furnishings and decor crafted by local artisans.
Entamanu Ngorongoro is a safari favorite. Because of its proximity to the crater, guests on game drives can reach the crater floor earlier than other tour groups, improving their chances of seeing the “Big Five" animals. The camp also provides guided hikes and bush picnics, so guests can explore the surrounding scenic highlands and interact with neighboring Maasai communities.
Because the camp is set high on the crater rim, nights can be chilly. Luckily, blazing fires, hot showers, and top-notch food and wine back at camp keep guests warm.

Camp Cecil, Baja - Isla Espiritu Santo, Mexico
Camp Cecil brings new meaning to sleeping on the beach: Its eight walk-in tents open up to the ocean, with the Sea of Cortez just steps away.
Not all modern conveniences are on offer at Camp Cecil. For instance, there’s no Wi-Fi, and the toilet facilities are shared. But those willing to ever-so-slightly rough it will find much to enjoy, from exploring vibrant marine life — guests can try scuba diving, kayaking or even swimming with sea lions — to learning about Mexican history at nearby attractions.
At outdoor lounge areas, visitors can nosh on fresh seafood and innovative cocktails, then search the sky for constellations at night. 

2012/10/18

Amazing undersea resturant


Ithaa Undersea Restuarant is Conrad Maldives Rangali Island's unique undersea restaurant 16 feet below sea level. 

Marvel at 180° views of reef and marine life,Maldivian-Western fusion cuisine at this spectacular Maldives venue – the world’s first all-glass undersea restaurant.